Functional RNA structures as targets in emerging arboviruses

Emerging arboviruses: Why today?

The recent global (re)emergence of arthropod-borne viruses (arboviruses), such as chikungunya and Zika virus, was widely reported in the media as though it was a new phenomenon. This is not the case. Arboviruses and other human microbial pathogens have been (re)emerging for centuries. The major difference today is that arbovirus emergence and dispersion are more rapid and geographically extensi...

Arboviruses and related viruses as emerging pathogens in Southeast Asia

A decade ago, increased reporting of the spread or appearance of emerging pathogens was observed by the scientific community, and emerging diseases at the time were defined. In order to evaluate the importance of this newly recognized nosological concept, comprehensive analyses were performed on different ecological aspects of germs, the epidemiology of diseases and factors of emergence. Along ...

Tropical Islands as New Hubs for Emerging Arboviruses

South America are genetically divergent and diverse (6,8). We hypothesize that the European population is poorly adapted to South American strains and therefore more susceptible to OT. If this hypothesis is true, Native Americans who had a long history of exposure to atypical strains from South America should be more resistant to OT. This hypothesis is reinforced by a recent survey conducted am...

Rhythms as emerging structures

RNA Structures as Mediators of Neurological Diseases and as Drug Targets

RNAs adopt diverse folded structures that are essential for function and thus play critical roles in cellular biology. A striking example of this is the ribosome, a complex, three-dimensionally folded macromolecular machine that orchestrates protein synthesis. Advances in RNA biochemistry, structural and molecular biology, and bioinformatics have revealed other non-coding RNAs whose functions a...